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la vie intra-utérine avant la production de testostérone le fœtus possède le même aspect extérieur
 » chez le foetus de sexe masculin, la testostérone est produite pendant la vie antenatale et joue un rôle essentiel dans la masculinisation des organes génitaux
immédiatement après la naissance, la testostérone continue à être produite pendant trois à six mois (on appelle cette période “minipuberté”) puis la production s’arrête pendant plus de 10 ans
elle recommence finalement lors de la puberté
la sécrétion de testostérone provient des cellules de leydig présentes au niveau des testicules
en quantité beaucoup plus faible, elle. est produite par les glandes surrénales, ce qui est négligeable chez l’homme mais important chez la femme
lors de la puberté, la testostérone permet l’apparition de certains caractères masculins spécifiques comme le développement des poils, le développement de l’appareil génital masculin et des muscles, l’apparition de la libido, le changement de la tonalité de la voix, etc
de plus, au niveau sexuel, cette hormone joue un rôle local  dans le testicule essentiel pour la maturation des spermatozoïdes
  « la testostérone reste en quelque sorte l’hormone de la sexualité et de la fertilité masculines »,. souligne le pr jacques young
elle joue également un rôle dans la poussée de croissance pubertaire des adolescents
elle rend les os plus solides en général (prévention de l’ostéoporose)
elle induit aussi une augmentation de la masse musculaire, d’où son utilisation (dangereuse et fréquente) dans le dopage  des sportifs
contrairement à une croyance largement répandue, les femmes ont également de la testostérone mais en nettement moindre quantité
précisément, la concentration de cette hormone est dix fois moins importante dans l’organisme féminin que dans l’organisme masculin
chez la femme, la testostérone est produite en partie par les ovaires et en partie par les glandes surrénales
elle pourrait contribuer au maintien de la libido
« a ce sujet, rien n’est vraiment certain
ce rôle sexuel physiologique chez la femme est largement débattu par la communauté scientifique », remarque le pr young
dans certains cas, il est important de doser la testostérone
 le dosage est fréquemment demandé pour les hommes ayant un pénis de petite taille ou quand la puberté ne se développe pas normalement », décrit le spécialiste
on en réalise également un quand, à l’âge adulte, les hommes souffrent de troubles de la libido (absence. d’envie sexuelle) ou d’autres problèmes sexuels comme les troubles de l’érection
chez la femme, un dosage est effectué quand existent des symptômes évoquant un excès de cette hormone : acné, peau et cheveux gras
et, surtout, devant une pilosité excessive à certains endroits du corps (moustache, menton, seins ou vers l’ombilic)
dans tous les cas où on suspecte une maladie altérant la testostérone, le dosage de la testostérone se réalise grâce à un prélèvement sanguin
quand le dosage de testostérone montre une insuffisance en testostérone chez l’homme (on parle d’hypogonadisme), une supplémentation peut être envisagée afin d’augmenter le taux mais surtout pour corriger les symptômes ayant motivé le dosage de cette hormone
johanna amselem pr jacques young, endocrinologue à l’hôpital universitaire de bicêtre (94))article mis à jour le 26 juin 2018
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playstation, nintendo revitalised its brand by launching a $185 million marketing campaign centered around the “play it loud” slogan
2 neufs  dès 99€99[28] during the same year, nintendo also released the game boy pocket in japan, a smaller version of the game boy that generated more sales for the platform

on 4 october 1997, famed nintendo developer gunpei yokoi died in a car crash
in 1997, nintendo released the sns-101 (called super famicom jr
in japan), a smaller redesigned version of the super nintendo entertainment system
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in 1998, the successor to the game boy, the game boy color, was released
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the system had improved technical specifications allowing it to run games made specifically for the system as well as games released for the game boy, albeit with added colour
the game boy camera and printer were also released as accessories
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in october 1998, retro studios was founded as an alliance between nintendo and former iguana entertainment founder jeff spangenberg
nintendo saw an opportunity for the new studio to create games for the upcoming gamecube targeting an older demographic, in the same vein as iguana entertainment’s successful turok series for the nintendo 64
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in 2001, nintendo introduced the redesigned game boy advance
the same year, nintendo also released the gamecube to lukewarm sales, and it ultimately failed to regain the market share lost by the nintendo 64
when yamauchi, company president since 1949, retired on 24 may 2002,[30][31] satoru iwata became first nintendo president who was unrelated to the yamauchi family through blood or marriage since its founding in 1889
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in 2003, nintendo released the game boy advance sp, a redesign of the game boy advance that featured a clamshell design that would later be used in nintendo’s ds and 3ds handheld video game systems2 jeux = 10€, 3 jeux = 20€

livraison gratuitein 2004, nintendo released the nintendo ds, its fourth major handheld system

the ds is a dual screened handheld featuring touch screen capabilities, which respond to either a stylus or the touch of a finger
former nintendo president and now chairman hiroshi yamauchi was translated by gamescience as explaining, “if we can increase the scope of the industry, we can re-energise the global market and lift japan out of depression – that is nintendo’s mission
” regarding lukewarm gamecube sales which had yielded the company’s first reported operating loss in over 100 years, yamauchi continued: “the ds represents a critical moment for nintendo’s success over the next two years
if it succeeds, we rise to the heavens, if it fails, we sink into hell
“[34][35][36] thanks to games such as nintendogs and mario kart ds, the ds became a success
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in 2005, nintendo released the game boy micro in north america, a redesign of the game boy advance
the last system in the game boy line, it was also the smallest game boy, and the least successful
in the middle of 2005, nintendo opened the nintendo world store in new york city, which would sell nintendo games, present a museum of nintendo history, and host public parties such as for product launches
the store was renovated and renamed as nintendo new york in 2016
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1 occasion  dès 49€32in the first half of 2006, nintendo released the nintendo ds lite, a version of the original nintendo ds with lighter weight, brighter screen, and better battery life

in addition to this streamlined design, its prolific subset of casual games appealed to the masses, such as the brain age series
meanwhile, new super mario bros
provided a substantial addition to the mario series when it was launched to the top of sales charts
the successful direction of the nintendo ds had a big influence on nintendo’s next home console (including the common nintendo wi-fi connection),[37] which had been codenamed “revolution” and was now renamed to “wii”
[citation needed ] in august 2006, nintendo published es, a now-dormant, open source research operating system project designed around web application integration but for no specific purpose
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in the latter half of 2006, nintendo released the wii as the backward-compatible successor to the gamecube
based upon intricate wii remote motion controls and a balance board, the wii inspired several new game franchises, some targeted at entirely new market segments of casual and fitness gaming
livraison gratuiteselling more than 100 million worldwide, the wii was the best selling console of the seventh generation, regaining market share lost during the tenures of the nintendo 64 and gamecube

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on 1 may 2007, nintendo acquired an 80% stake on video game development company monolith soft, previously owned by bandai namco
monolith soft is best known for developing role-playing games such as the xenosaga and baten kaitos series
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during the holiday season of 2008, nintendo followed up the success of the ds with the release of the nintendo dsi in japan
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the system features a more powerful cpu and more ram, two cameras, one facing towards the player and one facing outwards, and had an online distribution store called dsiware
the dsi was later released worldwide during 2009
in the latter half of 2009, nintendo released the nintendo dsi xl in japan, a larger version of the dsi
this updated system was later released worldwide in 2010
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in 2011, nintendo released the nintendo 3ds, based upon a glasses-free stereoscopic 3d display
in february 2012, nintendo acquired mobiclip, a france-based research and development company specialised in highly optimised software technologies such as video compression
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the company’s name was later changed to nintendo european research & development

[41] during the fourth quarter of 2012, nintendo released the wii u
it sold slower than expected,[42] despite being the first eighth generation console
quel jeu de combat réunit plus de 70 personnages jouables, tous issus desby september 2013, however, sales had rebounded

[clarification needed ] intending to broaden the 3ds market, nintendo released 2013’s cost-reduced nintendo 2ds
the 2ds is compatible with but lacks the 3ds’s more expensive but cosmetic autostereoscopic 3d feature
nintendo also released the wii mini, a cheaper and non-networked redesign of the wii
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on 25 september 2013, nintendo announced it had purchased a 28% stake in a panasonic spin-off company called pux corporation
jeu nintendo switch jeu musical sur switchthe company specialises in face and voice recognition technology, with which nintendo intends to improve the usability of future game systems

nintendo has also worked with this company in the past to create character recognition software for a nintendo ds touchscreen
[43] after announcing a 30% dive in profits for the april to december 2013 period, president satoru iwata announced he would take a 50% pay-cut, with other executives seeing reductions by 20%–30%
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in january 2015, nintendo announced its exit from the brazilian market after four years of distributing products in the country
jeu nintendo switch jeu d’action/aventure sur switchnintendo cited high import duties and lack of local manufacturing operation as reasons for leaving

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nintendo continues its partnership with juegos de video latinoamérica to distribute products to the rest of latin americaafin de continuer à améliorer la protection de vos données personnelles, nous avons mis à jour notre politique de confidentialité

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on 11 july 2015, iwata died from a bile duct tumor at the age of 55
following his death, representative directors genyo takeda and shigeru miyamoto jointly led the company on an interim basis until the appointment of tatsumi kimishima as iwata’s successor on 16 september 2015
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[46] in addition to kimishima’s appointment, the company’s management organisation was also restructured—miyamoto was named “creative fellow” and takeda was named “technology fellow”
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on 17 march 2015, nintendo announced a partnership with japanese mobile developer dena to produce games for smart devices
[48][49] the first of these, miitomo, was released in march 2016
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on the same day, nintendo announced a new “dedicated games platform with a brand new concept” with the codename “nx” that would be further revealed in 2016
[49][51] reggie fils-aimé, president of nintendo of america, referred to nx as “our next home console” in a june 2015 interview with the wall street journal
[52] in a later article from october 2015, the wall street journal relayed speculation from unnamed inside sources that the nx was intended to feature “industry leading” hardware specifications and be usable as both a home and portable console
it was also reported that nintendo had begun distributing software development kits (sdks) for it to third-party developers, with the unnamed source further speculating that these moves suggested that the company was on track to introduce it as early as 2016
[53] at an investor’s meeting on 27 april 2016, nintendo announced that the nx would be released worldwide in march 2017
[54] in an interview with asahi shimbun in may 2016, kimishima stated that the nx was a new concept that would not succeed the 3ds or wii u product lines
[55] at a shareholders’ meeting following e3 2016, shigeru miyamoto stated that the company chose not to present the nx during the conference due to concerns that competitors could copy from it if they revealed it too soon
[56] the same day, kimishima also revealed during a q&a session with investors that they were also researching virtual reality
in may 2015, universal parks & resorts announced that it was partnering with nintendo to create attractions at universal theme parks based upon nintendo properties
[58] in may 2016, nintendo also expressed a desire to enter the animated film market
[59] in november 2016, it was stated that the area to

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